The life of injectable dermal fillers depends on what’s used and where it’s placed. Around the mouth or in smile lines, results might soften sooner because of constant movement. Cheek or jawline work often holds longer. Hyaluronic acid formulas typically last half a year to a full year, while poly-L-lactic acid continues to work for over two years by prompting the skin to produce its own collagen. Options like fat grafting or PMMA can offer more staying power. Even within the same face, different areas age and change at different rates, which is why follow-up treatments keep results consistent.