Volume loss from aging, weight loss, or naturally thin body composition leaves many patients wanting fuller contours but lacking enough fat for surgical fat transfer. If you’ve been told you don’t have sufficient body fat for autologous fat grafting-or you simply want natural volume restoration without liposuction and its associated downtime-alloClae™ offers a different path. This revolutionary structural adipose filler uses processed donor human adipose tissue to restore lost volume across the face, breasts, hips, and body, all performed in office under local anesthesia with minimal downtime.
Dr. David Sieber, a board certified plastic surgeon at Sieber Plastic Surgery in San Francisco, now offers AlloClae injections for patients seeking smooth contours and natural looking volume without the surgical demands of traditional fat transfer.
Schedule a consultation to find out if AlloClae treatment is right for your goals.
AlloClae is the first commercially available structural adipose filler made from donor tissue-specifically, processed human adipose tissue recovered from carefully screened donors. Unlike synthetic fillers such as hyaluronic acid fillers, poly l lactic acid, or other collagen stimulator products, AlloClae is composed of real human tissue. And unlike autologous fat transfer, it requires no liposuction harvest from your own fat.
During manufacturing, fat cells and other immunogenic cellular components-including cellular debris and DNA-are removed through proprietary decellularization. What remains is the extracellular matrix: a three-dimensional “honeycomb” scaffold of connective tissue, collagen, growth factors, and residual lipids. This extracellular matrix in AlloClae acts as a scaffold for tissue integration, giving the product its ability to provide structural support and immediate volume upon injection.
AlloClae is regulated by the FDA under 21 CFR Part 1271 as an HCT/P (Human Cell and Tissue Product). This means it is minimally manipulated and intended for homologous use-placed in areas where adipose tissue naturally exists. It is important to understand that AlloClae is FDA-compliant under tissue product regulations rather than FDA-approved as a drug or medical device. Donor screening includes rigorous testing for communicable diseases, and the product undergoes terminal sterilization via gamma radiation to meet international safety standards.
The filler retains a high concentration of collagen and growth factors, which differentiates it from traditional fillers that rely on synthetic materials. AlloClae is packaged in syringes of 12.5 cc or 25 cc sizes and is manufactured by Tiger Aesthetics Medical LLC, with tissue recovery handled by RegenTX Partners, LLC. The product is stored at ambient temperature and has a shelf life of approximately three months.
The journey from donor tissue to injectable product involves multiple safety and processing steps. Donor adipose tissue is recovered under aseptic conditions from screened cadaveric sources. Medical and social history, serology, and microbiology testing are all completed before tissue is accepted for processing.
AlloClae is processed to remove immunogenic cellular components-viable adipocytes, stromal cells, and DNA-using proprietary buffers and surfactants. The result is a non-viable scaffold that preserves the natural architecture of soft tissue: collagen networks, growth factors, structural proteins, and residual triglycerides. Terminal sterilization with gamma radiation completes the process. Because all fat cells have been removed, the product does not depend on living cell survival for its effect, which sets it apart from autologous fat grafting where graft retention depends heavily on cell viability.
The injection procedure is minimally invasive and typically takes 30 to 90 minutes to complete. AlloClae is injected in a clinic under local anesthesia, using blunt-tip cannulas through small access points. The product is layered into the subcutaneous tissue at the injection site, filling areas of volume loss with immediate volume. Most patients notice an immediate improvement in contour, though temporary swelling and mild swelling are expected in the first several days.
Timeline of results: Patients see initial volume right away. Swelling settles over one to two weeks, and the scaffold begins integrating with surrounding tissue. Full results are typically seen around 3–6 months post-treatment as tissue integration and collagen production progress. The host body may form new capillaries and deposit its own tissue around the scaffold, contributing to tissue regeneration and a natural appearance.
Regarding longevity: Clinical experience suggests results from AlloClae may last around 1–3 years. Results typically last 12–18 months or longer, and some studies suggest semi-permanent benefits. Results may persist for 18 to 24 months in some patients, depending on the treatment area and volume injected. Touch-ups may be required every one to two years to maintain optimal results.
AlloClae is designed for body contouring rather than fine facial corrections, though it can be used anywhere fat naturally exists. Its versatility makes it suitable for patients seeking subtle enhancement or more substantial volume restoration across multiple areas.
Facial Volume Restoration
AlloClae can be used off-label for facial volume restoration in areas like the cheeks, temples, and under-eye hollows where moderate volume loss creates a hollow or aged appearance. For patients seeking to restore volume and improve skin texture in these areas, AlloClae offers natural looking volume that integrates with your own tissue.
Breast Enhancement and Asymmetry Correction
AlloClae can enhance breast volume and correct asymmetry without implants or surgical fat transfer. It is also used to address breast implant rippling or edge visibility, offering a less invasive alternative to revision surgery. Patients interested in comparing options may also want to learn about Breast Fat Transfer, which uses autologous fat from liposuction.
Buttocks and Hip Contouring
It effectively smooths hip dips and lifts the buttocks-two of the most common requests. Hip dip correction is one of the typical applications of AlloClae, with ongoing multi-center studies evaluating outcomes in this area. For patients considering more dramatic augmentation, Dr. Sieber also offers Brazilian Butt Lift procedures using your own fat.
Additional Treatment Areas
For patients who lack enough fat for traditional fat transfer or autologous fat grafting, AlloClae provides an alternative to traditional fat grafting that requires liposuction. You do not need sufficient body fat or a donor site-the donor tissue is ready to use.
AlloClae cost varies based on treatment area, volume needed, and the number of sessions required to achieve your desired shape. Because patients often require multiple syringes for adequate volume, total investment depends on the scope of treatment.
General pricing ranges:
Factors affecting cost AlloClae:
AlloClae is more expensive than traditional fillers due to processing, donor screening, and sterilization requirements. However, because AlloClae results can last 12 to 18 months or longer-significantly beyond many hyaluronic acid or poly l lactic acid options-the cost per month of benefit may be comparable.
AlloClae treatment for aesthetic medicine and body contouring is typically self-pay and not covered by insurance. Many practices, including Sieber Plastic Surgery, can discuss financing options during your consultation. A personalized treatment plan with a detailed cost estimate is provided after evaluation.
AlloClae is regulated by the FDA as an HCT/P (Human Cell and Tissue Product), ensuring rigorous donor screening and sterile processing. Because fat cells and DNA are removed, immune response risks are minimized. Common mild side effects include temporary swelling and bruising. Dr. Sieber reviews all safety protocols during your evaluation.
Clinical outcomes typically last 12 to 18 months, with some patients maintaining volume for up to 2 years. Touch-up treatments can be performed every 1 to 2 years to sustain your ideal contour long-term.
Yes. This is one of AlloClae’s main advantages. Since it utilizes donor tissue, lean patients who lack sufficient donor fat for a traditional fat transfer or Brazilian Butt Lift can achieve natural volume restoration without liposuction.
Recovery involves minimal downtime. Performed in-office under local anesthesia, patients avoid surgical incisions and donor-site pain. Most patients experience mild swelling and return to normal daily activities within 2 to 3 days.
Yes. AlloClae is frequently used after Liposuction to correct contour irregularities, fill divots, and smooth out uneven areas for a refined final result.
Sieber Plastic Surgery · San Francisco, CA
Tiger BioSciences – AlloClae Product Information
PMC – Advancing Soft Tissue Reconstruction with Human Adipose Allograft
Tiger Aesthetics Medical – Instructions for Use (IFU)
The information on this page is intended for educational purposes and does not constitute medical advice. Individual results vary. AlloClae is regulated as an HCT/P under FDA tissue product rules and is not FDA-approved as a drug or device. All medical decisions should be made in consultation with a qualified, board-certified physician. No specific outcomes are guaranteed.
